Nginx is the most popular HTTP server next to Apache, and it is also a reverse proxy and mail proxy server. The name nginx comes from "engine X" which sounds like a secret weapon, and in fact, it is remarkable for its high performance, low-resource usage, and legacy stability.

Install nginx

Install nginx is very easy, you can follow the instruction from the official nginx website.
Here is an example for debian 8:

1.Add apt source

vi /etc/apt/sources.list.d/nginx.list
deb http://nginx.org/packages/debian/ stretch nginx

2.Import apt key
wget --quiet -O - http://nginx.org/keys/nginx_signing.key | apt-key add -

3.Update packages and install

apt-get update
apt-get install nginx

Optimize configuration

1.Edit the main configuration
vi /etc/nginx/nginx.conf

Change worker_processes to the core number of the CPU, 2, 4 or 8.
worker_processes 2;

Add epoll for events, worker_connections is the max number of concurrency connections per process.

events {
    use epoll;
    worker_connections  1024;
}

Optimize TCP connections

http {
    sendfile    on;
    tcp_nopush  on;
    tcp_nodelay on;
    keepalive_timeout  65;
}

Enable gzip compression

http {
    gzip  on;
    #gzip_static on;
    gzip_comp_level 5;
    gzip_min_length 1k;
    gzip_proxied any;
    gzip_types text/plain text/javascript text/xml aplication/xml application/xml+rss;
    gzip_vary on;
}

2.Edit the default configuration
vi /etc/nginx/conf.d/default.conf

Listening for IPv6
listen [::]:80;

Change document root and index
mkdir -p /var/www/html

location / {
    root   /var/www/html;
    index  index.html index.htm;
}

Configuration for scripts(uwsgi)

1.Configuration for PHP

server {
    listen 80;
    server_name localhost;

    location / {
        root   /var/www/html;
        index  index.html index.htm index.php;
    }

    location ~ \.php$ {
        root /var/www/html;
        uwsgi_pass unix:/var/tmp/uwsgi_php.sock;
        uwsgi_modifier1 14;
        include uwsgi_params;
    }
}

2.Configuration for Python

server {
    listen 80;
    server_name localhost;

    location / {
        uwsgi_pass unix:/var/tmp/uwsgi_django.sock;
        uwsgi_modifier1 30;
        include uwsgi_params;
    }
}

3.Configuration for Redmine

server {
    listen 80;
    server_name localhost;
    root /var/www/redmine/public;

    location ~* \.(ico|css|js|html)$ {
        root /var/www/redmine/public;
    }

    location ~* /images/ {
        root /var/www/redmine/public;
    }

    location / {
        uwsgi_pass unix:/var/tmp/uwsgi_redmine.sock;
        uwsgi_modifier1 7;
        include uwsgi_params;
    }
}

4.Configuration for Ghost

upstream ghost {
    server unix:/var/tmp/ghost.sock;
}

server {
    listen 80;
    server_name localhost;

    location /content/images {
       alias /var/www/ghost/content/images;
    }

    location /assets {
        alias /var/www/ghost/content/themes/casper/assets;
    }

    location /public {
        alias /var/www/ghost/core/built/public;
    }

    location /ghost/scripts {
        alias /var/www/ghost/core/built/scripts;
    }

    location / {
        proxy_set_header X-Real-IP $remote_addr;
        proxy_set_header Host $http_host;
        proxy_set_header X-Forwarded-For $proxy_add_x_forwarded_for;
        #Enable SSL
        #proxy_set_header X-Forwarded-Proto https;
        proxy_pass http://ghost;
    }
    access_log off;
}

5.Configuration for SSL

server {
    listen       443 ssl;
    server_name  localhost;

    ssl_certificate      /etc/nginx/cert.pem;
    ssl_certificate_key  /etc/nginx/cert.key;
    ssl_session_cache shared:SSL:1m;
    ssl_session_timeout  5m;
    ssl_ciphers  HIGH:!aNULL:!MD5;
    ssl_prefer_server_ciphers   on;

    location / {
        root   /var/www/html;
        index  index.html index.htm;
    }
}

In order to use unix socket, nginx and uwsgi must both run as the user nginx. See my previous post for uwsgi configuration.